Therapeutic Effect of Vernonia Amygdalina Aqueous Leaf Extract on Salmonella Typhimurium-Infected Female Wistar Rats

This study investigated the therapeutic effects of Vernonia amygdalina aqueous leaf extract administration on Salmonella typhimurium infected Wistar rats. Rats were orally by a single dose (1.5 x 108 CFU). Negative control groups and treated with vehicle (distilled water), neutral group not infected, while four test up to 24 days 50 mg/kg. 100 mg/kg, 150 mg/kg 200 body weight V. respectively. The serum markers (amino transferase activities, total protein, creatinine bilirubin levels), as well histopathology liver kidney tissues also investigated. Following in vivo studies, was effective alleviating damage seen amino activity. Infection resulted significant increase drug plant helped alleviate from infection observed organ weights their protein content. Findings this showed that at higher doses ameriolation tissue caused S. Typhi bacteria (from histological studies). These results support ethnomedicinal use amygdalina, posits its leaves can be used antibacterial phytomedicine.